Immunity, Chapter 02, Signaling and Adhesive Molecules of the Immune System

Table of Contents

1. 2-1 The Immunoglobulin Superfamily: Structural Features
2. 2-2 Signaling by Immunoglobulin Superfamily Receptors
3. 2-3 Adhesion Molecules of the Immunoglobulin Superfamily
4. 2-4 Integrins in Immune Function
5. 2-5 C-Type Lectins and Carbohydrate Recognition
6. 2-6 Cytokines and Cytokine Receptors
7. 2-7 Cytokine Receptors that Signal via the Jak-STAT Pathway
8. 2-8 Shared Subunits in Subfamilies of Type I Cytokine Receptors
9. 2-9 The TNF Superfamily of Cell Regulators
10. 2-10 NF-κB and Inflammatory Cytokine Action
11. 2-11 Molecular Control of Apoptosis
12. 2-12 Regulation of Apoptosis by Bcl-2 Family Members
13. 2-13 Chemokines and Chemokine Receptors
14. 2-14 Chemokines, Integrins and Selectins and Immune-Cell Homing

2-12 Regulation of Apoptosis by Bcl-2 Family Members

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1	Which, if any, of the following are inhibitors of apoptosis? a) Bim. b) Bid. c) Bcl-XL. d) Puma. e) Bak. CorrectWrong: c is correct.Your answer has been saved.

2

Which of the following statements are true? a) Apoptotic effector members of the Bcl-2 family are normally inhibited by the prosurvival family members. b) The BH3-only members of the Bcl-2 family of apoptotic regulators are antiapoptotic. c) Cytokines inhibit the antiapoptotic actions of Bcl-2. d) One mechanism of activation for proapoptotic sensor members of the Bcl-2 family is cleavage by caspase. CorrectWrong: a and d are true.Your answer has been saved.