Immunity, Chapter 02, Signaling and Adhesive Molecules of the Immune System

Table of Contents

1. 2-1 The Immunoglobulin Superfamily: Structural Features
2. 2-2 Signaling by Immunoglobulin Superfamily Receptors
3. 2-3 Adhesion Molecules of the Immunoglobulin Superfamily
4. 2-4 Integrins in Immune Function
5. 2-5 C-Type Lectins and Carbohydrate Recognition
6. 2-6 Cytokines and Cytokine Receptors
7. 2-7 Cytokine Receptors that Signal via the Jak-STAT Pathway
8. 2-8 Shared Subunits in Subfamilies of Type I Cytokine Receptors
9. 2-9 The TNF Superfamily of Cell Regulators
10. 2-10 NF-κB and Inflammatory Cytokine Action
11. 2-11 Molecular Control of Apoptosis
12. 2-12 Regulation of Apoptosis by Bcl-2 Family Members
13. 2-13 Chemokines and Chemokine Receptors
14. 2-14 Chemokines, Integrins and Selectins and Immune-Cell Homing

2-10 NF-κB and Inflammatory Cytokine Action

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following is or are (an) essential step(s) in the classical pathway induced by receptor activation that leads to nuclear translocation and DNA binding by NF κB? a) Dimerization of the two subunits of NF-κB. b) Phosphorylation of IKKα. c) Phosphorylation of I-κB. d) Ubiquitination of I-κB. CorrectWrong: c and d are correct.Your answer has been saved.

2

Which of the following statements are true? a) All NF-κB family members contain the Rel homology domain that binds DNA. b) All NF-κB family members contain activation domains whereby gene transcription is stimulated. c) An important function of NF-κB family members is to promote cell survival. d) I-κBβ is the member of the I-κB family that is induced by NF-κB and terminates NF-κB activation by binding to it in the nucleus and shuttling it back to the cytoplasm. CorrectWrong: a and c are true.Your answer has been saved.