Immunity, Chapter 02, Signaling and Adhesive Molecules of the Immune System

Table of Contents

1. 2-1 The Immunoglobulin Superfamily: Structural Features
2. 2-2 Signaling by Immunoglobulin Superfamily Receptors
3. 2-3 Adhesion Molecules of the Immunoglobulin Superfamily
4. 2-4 Integrins in Immune Function
5. 2-5 C-Type Lectins and Carbohydrate Recognition
6. 2-6 Cytokines and Cytokine Receptors
7. 2-7 Cytokine Receptors that Signal via the Jak-STAT Pathway
8. 2-8 Shared Subunits in Subfamilies of Type I Cytokine Receptors
9. 2-9 The TNF Superfamily of Cell Regulators
10. 2-10 NF-κB and Inflammatory Cytokine Action
11. 2-11 Molecular Control of Apoptosis
12. 2-12 Regulation of Apoptosis by Bcl-2 Family Members
13. 2-13 Chemokines and Chemokine Receptors
14. 2-14 Chemokines, Integrins and Selectins and Immune-Cell Homing

2-9 The TNF Superfamily of Cell Regulators

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Of the following actions of TNF-related molecules, which is or are particularly associated with membrane-bound members of the family? a) Induction of inflammation. b) Induction of programmed cell death (apoptosis). c) Induction of lymphoid tissues. d) Interactions between immune cells in the initiation and effector phases of adaptive immune responses. CorrectWrong: b, c and d are correct.Your answer has been saved.

2

Which of the following statements are true? a) FADD is an adaptor that functions both in proapoptotic and in transcriptional regulatory actions of TNF recepors. b) Proaptotic signaling from TNF receptors activates caspases. c) TNF receptors that induce programmed cell death contain cytoplasmic death domains. d) TRAFs are adaptors linking TNF receptors to caspase activation. CorrectWrong: b and c are true.Your answer has been saved.