Immunity, Chapter 02, Signaling and Adhesive Molecules of the Immune System

Table of Contents

1. 2-1 The Immunoglobulin Superfamily: Structural Features
2. 2-2 Signaling by Immunoglobulin Superfamily Receptors
3. 2-3 Adhesion Molecules of the Immunoglobulin Superfamily
4. 2-4 Integrins in Immune Function
5. 2-5 C-Type Lectins and Carbohydrate Recognition
6. 2-6 Cytokines and Cytokine Receptors
7. 2-7 Cytokine Receptors that Signal via the Jak-STAT Pathway
8. 2-8 Shared Subunits in Subfamilies of Type I Cytokine Receptors
9. 2-9 The TNF Superfamily of Cell Regulators
10. 2-10 NF-κB and Inflammatory Cytokine Action
11. 2-11 Molecular Control of Apoptosis
12. 2-12 Regulation of Apoptosis by Bcl-2 Family Members
13. 2-13 Chemokines and Chemokine Receptors
14. 2-14 Chemokines, Integrins and Selectins and Immune-Cell Homing

2-7 Cytokine Receptors that Signal via the Jak-STAT Pathway

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Which of the following statements are true? The specificity of cellular responses to type I cytokines depends primarily on: a) the Jaks associated with the receptor. b) the sequences at the tyrosine phosphorylation sites in the cytoplasmic domains of the receptor. c) selective recruitment of STATs to the receptor. d) selective binding of regulatory regions in DNA by activated Jaks. CorrectWrong: b and c are true.Your answer has been saved.

2

Which of the following statements are true? a) The SH2 domains of STATs bind both to phosphotyrosines both on type I and II cytokine receptors and to phosphotyrosines on other STATs. b) IL-1 and IL-10 are type I cytokines. c) Activated STATs can form heterodimers. CorrectWrong: a and c are true.Your answer has been saved.