Immunity, Chapter 02, Signaling and Adhesive Molecules of the Immune System

Table of Contents

1. 2-1 The Immunoglobulin Superfamily: Structural Features
2. 2-2 Signaling by Immunoglobulin Superfamily Receptors
3. 2-3 Adhesion Molecules of the Immunoglobulin Superfamily
4. 2-4 Integrins in Immune Function
5. 2-5 C-Type Lectins and Carbohydrate Recognition
6. 2-6 Cytokines and Cytokine Receptors
7. 2-7 Cytokine Receptors that Signal via the Jak-STAT Pathway
8. 2-8 Shared Subunits in Subfamilies of Type I Cytokine Receptors
9. 2-9 The TNF Superfamily of Cell Regulators
10. 2-10 NF-κB and Inflammatory Cytokine Action
11. 2-11 Molecular Control of Apoptosis
12. 2-12 Regulation of Apoptosis by Bcl-2 Family Members
13. 2-13 Chemokines and Chemokine Receptors
14. 2-14 Chemokines, Integrins and Selectins and Immune-Cell Homing

2-6 Cytokines and Cytokine Receptors

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Paracrine signaling by cytokines occurs: a) between neighboring cells. b) when a cytokine binds receptors on the producing cell itself. c) through membrane-bound cytokines binding to receptors. d) through soluble cytokines binding to receptors. CorrectWrong: a, c and d are correct.Your answer has been saved.

2

Which of the following statements are true? a) The IL-1 receptor family includes the Toll-like receptors. b) Some members of the TGF- β cytokine family are immunosuppressive. c) The type I and type II kinase domains of the TGF- β cytokine family receptors cross-phosphorylate one another. d) Tyrosine kinase receptors for growth factors acting in hematopoiesis are activated by dimerization. e) The M-CSF receptor is a member of the TGF- β receptor family. CorrectWrong: b and d are true.Your answer has been saved.