Immunity, Chapter 02, Signaling and Adhesive Molecules of the Immune System

Table of Contents

1. 2-1 The Immunoglobulin Superfamily: Structural Features
2. 2-2 Signaling by Immunoglobulin Superfamily Receptors
3. 2-3 Adhesion Molecules of the Immunoglobulin Superfamily
4. 2-4 Integrins in Immune Function
5. 2-5 C-Type Lectins and Carbohydrate Recognition
6. 2-6 Cytokines and Cytokine Receptors
7. 2-7 Cytokine Receptors that Signal via the Jak-STAT Pathway
8. 2-8 Shared Subunits in Subfamilies of Type I Cytokine Receptors
9. 2-9 The TNF Superfamily of Cell Regulators
10. 2-10 NF-κB and Inflammatory Cytokine Action
11. 2-11 Molecular Control of Apoptosis
12. 2-12 Regulation of Apoptosis by Bcl-2 Family Members
13. 2-13 Chemokines and Chemokine Receptors
14. 2-14 Chemokines, Integrins and Selectins and Immune-Cell Homing

2-4 Integrins in Immune Function

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Integrin binding to adhesive molecules on other cells is regulated by: a) conformational changes induced by signaling molecules on the same cell that increase its affinity for its ligand. b) changes in the lateral mobility of the integrin molecules that allow clustering. c) phosphorylation of their cytoplasmic domains. d) inside-out signaling. CorrectWrong: a, b and d are correct.Your answer has been saved.

2

Which of the following statements are true? a) The avidity of integrin binding to its ligands is increased by inside-out signalling. b) The α and β chains of integrins can be expressed in different combinations on different cells. c) The cytoplasmic domain of the α chain of integrins associates with proteins that regulate the assembly of actin filaments. d) Changes in integrin expression contribute to changes in the tissue-specific localization of cells. CorrectWrong: a, b and d are true.Your answer has been saved.