Immunity, Chapter 02, Signaling and Adhesive Molecules of the Immune System

Table of Contents

1. 2-1 The Immunoglobulin Superfamily: Structural Features
2. 2-2 Signaling by Immunoglobulin Superfamily Receptors
3. 2-3 Adhesion Molecules of the Immunoglobulin Superfamily
4. 2-4 Integrins in Immune Function
5. 2-5 C-Type Lectins and Carbohydrate Recognition
6. 2-6 Cytokines and Cytokine Receptors
7. 2-7 Cytokine Receptors that Signal via the Jak-STAT Pathway
8. 2-8 Shared Subunits in Subfamilies of Type I Cytokine Receptors
9. 2-9 The TNF Superfamily of Cell Regulators
10. 2-10 NF-κB and Inflammatory Cytokine Action
11. 2-11 Molecular Control of Apoptosis
12. 2-12 Regulation of Apoptosis by Bcl-2 Family Members
13. 2-13 Chemokines and Chemokine Receptors
14. 2-14 Chemokines, Integrins and Selectins and Immune-Cell Homing

2-1 The Immunoglobulin Superfamily: Structural Features

Work through the following questions, checking all the correct answers. For each question there may be more than one correct answer.

1

Framework residues are: a) the amino-acid residues that form the constant domains of immunoglobulins. b) the amino-acid residues that are necessary for the formation of disulfide bonds in an immunoglobulin or immunoglobulin-like domain. c) all of the amino-acid residues forming an immunoglobulin or immunoglobulin-like domain. d) the amino-acid residues forming the beta sandwich of an immunoglobulin variable region. CorrectWrong: d is correct.Your answer has been saved.

2

Which of the following statements are true? a) Interactions with other molecules can occur at any site on an immunoglobulin or immunoglobulin-like domain. b) The Ig superfamily is the name given to immunoglobulin and immunoglobulin-like proteins with specialized functions in immunity. c) The structural features of immunoglobulin-superfamily proteins make them particularly well adapted to function in an extracellular environment. CorrectWrong: a and c are correct.Your answer has been saved.