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Question 1

Which of the following is correct regarding iron deficiency anaemia?

a) Lack of iron interrupts the final stage of globin synthesis.

b) Inadequate dietary intake of iron is the commonest cause of iron deficiency.

c) All patients with iron deficiency anaemia should have investigation of their gastrointestinal tract.

d) The blood film shows a microcytic hypochromic picture.

Question 2

Which of the following is correct regarding megaloblastic anaemia?

a) Megaloblasts are large circulating red cells.

b) The commonest causes of megaloblastic anaemia are vitamin B12 deficiency and folate deficiency.

c) Vitamin B12 deficiency is usually due to inadequate dietary intake.

d) Folate deficiency is usually due to malabsorption.

Question 3

Which of the following is correct regarding inherited haemolytic anaemias?

a) A raised reticulocyte count with numerous spherocytes on the blood film is diagnostic of hereditary spherocytosis.

b) Most people with glucose 6 phosphate dehydrogenase deficiency have a mild asymptomatic anaemia.

c) Sickle cell disease is diagnosed by a positive sickle cell solubility test.

d) Anaemia in thalassaemia is a result of ineffective erythropoiesis and haemolysis.

Question 4

Which of the following is correct regarding haemostasis?

a) Tissue factor initiates the coagulation cascade.

b) Plasmin stimulates the conversion of fibrinogen into fibrin.

c) Thrombin, protein C, and protein S are natural anticoagulants that control coagulation by inactivating clotting factors.

d) Factor V Leiden mutation causes resistance to activated protein S.

Question 5

Which of the following is correct regarding thrombocytopenia?

a) Petechiae do not occur until the platelet count falls below 75 x 10⁹/litre.

b) Idiopathic thrombocytopenic purpura typically presents with an isolated thrombocytopenia in an otherwise well patient.

c) In adults, idiopathic thrombocytopenic purpura usually resolves within 1-2 months.

d) Patients with heparin induced thrombocytopenia are at particular risk of bleeding.

Question 6

Which of the following is correct regarding clotting disorders?

a) Von Willebrand disease leads to an isolated prolonged bleeding time due to a defect in primary haemostasis.

b) Haemophilia B is due to a deficiency of factor XI.

c) The INR is used to assess the severity of liver failure.

d) Placental abruption is the commonest cause of acute disseminated intravascular coagulation.

Question 7

Which of the following is correct regarding chronic lymphocytic leukaemia?

a) Most patients present with lymphadenopathy.

b) An autoimmune haemolytic anaemia is a well recognized complication.

c) It has an aggressive course with the rapid onset of bone marrow failure.

d) The disease often terminates by transforming into an acute leukaemia.

Question 8

Which of the following is correct regarding non Hodgkin lymphomas?

a) B and T lymphocyte types are about equal in incidence.

b) They arise from lymphocytes in the bone marrow.

c) They typically present with solid masses at lymph nodes or extranodal sites.

d) Follicular lymphoma is an aggressive non Hodgkin lymphoma.

Question 9

Which of the following is correct regarding Hodgkin lymphomas?

a) Nodular lymphocyte predominant Hodgkin lymphoma is one subtype of classical Hodgkin lymphoma.

b) Classical Hodgkin lymphoma typically involves inguinal lymph nodes.

c) Accurate diagnosis of the type of Hodgkin lymphoma can made on clinical and radiological grounds.

d) The Hodgkin Reed Sternberg cell is a mutated B lymphocyte.

Question 10

Which of the following is correct regarding myeloma?

a) It may come to light following pneumonia.

b) Definitive diagnosis requires finding large numbers of abnormal plasma cells in the peripheral blood.

c) Renal impairment is caused by immunoglobulin heavy chains becoming stuck in the renal tubular system.

d) It can be cured with chemotherapy.

Oxford University Press, Online Resource Centre, Chapter 15.

Chapter 15

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