Chapter 05

Instructions

Choose your answers from a-d by clicking the radio button next to each choice and then press 'Submit' to get your score.

Which of the following is correct regarding classification and nomenclature of neoplasms?

a) The histogenesis of a tumour refers to its behaviour.

b) An acanthoma is a benign tumour of glandular epithelium.

c) A carcinoma is an epithelial malignancy.

d) Leiomyosarcoma is a malignant tumour of skeletal muscle.

Which of the following is correct regarding proto-oncogenes?

a) They code for proteins that promote cell division.

b) MYC codes for a tyrosine kinase growth receptor.

c) MET codes for a transcription factor.

d) KIT is characteristically activated in gastric lymphomas.

Which of the following is correct regarding tumour suppressor genes?

a) RB is an example of a caretaker gene.

b) BRCA1 is an example of a gatekeeper gene.

c) CDKN2A codes for a protein called p16 which acts at the G1 to S checkpoint of the cell cycle.

d) The E7 protein of human papillomavirus targets p53 for degradation.

Which of the following is correct regarding metastasis?

a) Metastasis refers to infiltration of surrounding tissues by a malignant tumour.

b) Most cells shedding from a malignant tumour into the blood will successfully form a metastatic deposit.

c) Breast carcinomas commonly spread to the supraclavicular lymph nodes.

d) Renal cell carcinomas have a recognized tendency to spread to bone.

Which of the following is correct regarding a patient with a malignant neoplasm?

a) Hypercalcaemia due to bony metastases is an example of a paraneoplastic syndrome.

b) The tumour marker alpha-fetoprotein is usually raised in patients with hepatocellular carcinoma.

c) The grade of a neoplasm refers to how far it has spread.

d) Venous thrombosis is particularly associated with squamous cell carcinomas.