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Choose your answers from a-d by clicking the radio button next to each choice and then press 'Submit' to get your score.

Which of the following is correct regarding innate immunity?

a) The two principle phagocytes are macrophages and eosinophils.

b) C-reactive protein binds to microbial surfaces and triggers activation of complement.

c) The alternative pathway of complement activation is triggered by antibodies bound to a microbe.

d) The C3b molecule acts as an opsonin.

Which of the following is correct regarding humoral immunity?

a) Successful activation of naïve B lymphocytes requires help from CD8+ helper T lympocytes.

b) Activated B lymphocytes enter the germinal centre of lymphoid follicle and undergo class switching and somatic hypermutation.

c) The Fc portion of an antibody is the antigen binding region.

d) Immunoglobulin M is the major immunoglobulin in serum.

Which of the following is correct regarding cellular immunity?

a) Developing T cells that bind too strongly or too weakly to self-MHC molecules in the thymus are deleted by apoptosis.

b) CD4+ helper T lymphocytes recognized antigen bound to MHC class I molecules.

c) Full activation of T lymphocytes requires a costimulatory signal via the B7 protein on the T lymphocyte cell surface.

d) The Th2 subset of T helper lymphocytes activates macrophages via the cytokine interferon-g.

Which of the following is correct regarding hypersensitivity reactions?

a) Type I hypersensitivity reactions are also known as delayed-type hypersensitivity.

b) Hypersensitivity pneumonitis is due to a combination of type II and type IV hypersensitivity reactions.

c) The dominant mode of injury in systemic lupus erythematosus is a type III hypersensitivity reaction.

d) Anaphylaxis is a severe form of type IV hypersensitivity.

Which of the following is correct regarding human immunodeficiency virus (HIV) infection?

a) Inoculation of the virus through contaminated needles is the dominant mode of transmission.

b) Gastrointestinal infection by Mycobacterium avium intracellulare is a common cause of persistent diarrhoea.

c) Meningitis caused by Cryptosporidium is a well recognized infection.

d) Kaposi's sarcoma is related to human papillomavirus infection.

Oxford University Press, Online Resource Centre, Chapter 04.