Young: Medical Genetics - Extended Matching Questions

Table of Contents

1. Chapter 12
   1. Question 1
   2. Question 2

Question 2

Instructions: Each group of extended matching questions consists of lettered options followed by a list of numbered problems/questions. For each numbered problem/question select the one lettered option that is most closely answers the question. You can use the lettered options once, more than once, or not at all.

Theme: Gene therapy

Options:

1. Transdifferentiation
2. Transduction
3. Transfection
4. Transformation
5. Transgenesis
6. Transition
7. Transversion

Select the correct term to describe the following processes from the available options.

1

Scenario 1   Non-viral mediated gene transfer Choose... Transdifferentiation Transduction Transfection Transformation Transgenesis Transition Transversion Transfection refers to non-viral methods of gene transfer considered for gene therapy. These include the use of liposomes and direct injection of DNA. See Page 235.Incorrect. See Page 235.Your answer has been saved.

2	Scenario 2   Viral mediated gene transfer Choose... Transdifferentiation Transduction Transfection Transformation Transgenesis Transition Transversion Viruses used in transduction include adenoviruses and retroviruses. See Page 234.Incorrect. See Page 234.Your answer has been saved.

3

Scenario 3   Transfer of an exogenous gene into a cell Choose... Transdifferentiation Transduction Transfection Transformation Transgenesis Transition Transversion Transgenesis can be defined as the transfer of exogenous genes into plants or animals in an attempt to generate a different phenotype. See Page 233.Incorrect. See Page 233.Your answer has been saved.

4

Scenario 4   Malignant change in a cell Choose... Transdifferentiation Transduction Transfection Transformation Transgenesis Transition Transversion Transformation can be achieved by transfer of an oncogenic virus into a cell. Transformation also refers to the insertion of foreign DNA into a bacterium. See Page 188 and 233.Incorrect. See Page 188 and 233.Your answer has been saved.

5

Scenario 5   Change in tissue specificity Choose... Transdifferentiation Transduction Transfection Transformation Transgenesis Transition Transversion This is the process whereby cells which appear to have achieved fixed tissue-specificity can be manipulated to show a different organ or tissue specificity. See Page 236.Incorrect. See Page 236.Your answer has been saved.