Young: Medical Genetics - Extended Matching Questions

Table of Contents

1. Chapter 6
   1. Question 1
   2. Question 2

Question 2

Instructions: Each group of extended matching questions consists of lettered options followed by a list of numbered problems/questions. For each numbered problem/question select the one lettered option that is most closely answers the question. You can use the lettered options once, more than once, or not at all.

Theme: Complex diseases

Options:

1. 1%
2. 5%
3. 10-15%
4. 35%
5. 50%
6. 100%

Select the most appropriate recurrence risk for the following individuals from the available options.

1

Scenario 1   A 30-year-old man whose mother and maternal grandfather developed Alzheimer disease in their 50s. Choose... 1% 5% 10-15% 35% 50% 100% This family history is much more suggestive of a rare autosomal dominant form of Alzheimer disease than of the more common multifactorial type. See Page 125.Incorrect. See Page 125.Your answer has been saved.

2

Scenario 2   The young daughter of a 27-year-old woman who developed insulin-dependent diabetes mellitus (IDDM) at age 7 years. Choose... 1% 5% 10-15% 35% 50% 100% Sibling and offspring risks for an isolated case of IDDM are approximately 5%. The risk would be higher if other relatives have been affected. See Page 127.Incorrect. See Page 127.Your answer has been saved.

3

Scenario 3   The unborn baby of a woman who had a brother with spina bifida. Choose... 1% 5% 10-15% 35% 50% 100% When assessing the risk, determine the relationship between the affected individual and the person for whom a recurrence risk is sought. This unborn baby has had an affected second degree relative. See Page 129.Incorrect. See Page 129.Your answer has been saved.

4	Scenario 4   A 22-year-old man who has just learned that his identical twin brother has developed schizophrenia. Choose... 1% 5% 10-15% 35% 50% 100% The concordance rate for schizophrenia in monozygotic twins is 50-70% See Page 130.Incorrect. See Page 130.Your answer has been saved.

5

Scenario 5   The daughter of a woman who has unipolar depression. Choose... 1% 5% 10-15% 35% 50% 100% The risk to both siblings and offspring for first degree relatives is 10-15%. This is higher than for most other multifactorial disorders. See Page 131.Incorrect. See Page 131.Your answer has been saved.